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COURSE NUMBER: CHEM 460
COURSE TITLE: Synthesis, Purification, and Characterization
NAME OF INSTRUCTOR: Dr. Leah Martin-Visscher
CREDIT WEIGHT AND WEEKLY TIME DISTRIBUTION: credits 3(hrs lect 2 - hrs sem 0 - hrs lab 4)
COURSE DESCRIPTION: An advanced, integrated laboratory course utilizing synthetic methods from organic, inorganic and biochemistry. Students will perform a series of multi-step syntheses, followed by product purification and characterization, using chromatographic and spectroscopic methods extensively. Synthetic techniques will include solid-phase synthesis and work with air-sensitive materials.

Prerequisites: CHEM 351f
REQUIRED TEXTS:
  • Silverstein, R. M.; Webster, F.X.; Kiemle, D. J.; Bryce, D.L. Spectrometric Identification of Organic Compounds, 8th Edition, John Wiley & Sons, Inc.;  New York, 2014.
  • Zubrick, J. W. The Organic Chem Lab Survival Manual 9th Edition; John Wiley & Sons, Hoboken, NJ, 2004.
MARK DISTRIBUTION IN PERCENT:
Midterm Exam (open book)15%
Final Exam (open book)20%
Assignments15%
Laboratory45%
Participation5%
100%
COURSE OBJECTIVES:
  • To develop competence and confidence in the use of organic laboratory techniques of synthesis, separation and characterization.
  • To gain expertise in the hands-on use of modern spectroscopic tools for determination of molecular structure, including NMR, IR, GC-MS and UV-VIS
  • To actively search and read scientific literature and to practice writing formal scientific reports
  • To encourage positive, constructive interaction and collaboration amongst students and between students and instructors
  • To recognize your roles and responsibilities in the collection, interpretation and dissemination of scientific data
SCHEDULE OF TOPICS:
  • Physical properties of organic compounds and purity
  • Separation & Purification Techniques
    • Chromatography
    • Extraction
    • Distillation
    • Crystalllization
  • Spectroscopic techniques
    • Mass Spectrometry (MS)
    • Infrared Spectroscopy (IR)
    • NMR (including heteronuclear and multidimensional NMR)
    • UV-VIS
  • Laboratory Research
    • Designing experiments and working in the lab
    • Report Writing


Required texts, assignments, and grade distributions may vary from one offering of this course to the next. Please consult the course instructor for up to date details.

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