CHEM 460 Outline

COURSE NUMBER:

CHEM 460

COURSE TITLE:

Synthesis, Purification, and Characterization

NAME OF INSTRUCTOR:

Dr. Leah Martin-Visscher

CREDIT WEIGHT AND WEEKLY TIME DISTRIBUTION:

credits 3(hrs lect 2 - hrs sem 0 - hrs lab 4)

COURSE DESCRIPTION:

An advanced, integrated laboratory course utilizing synthetic methods from organic, inorganic and biochemistry. Students will perform a series of multi-step syntheses, followed by product purification and characterization, using chromatographic and spectroscopic methods extensively. Synthetic techniques will include solid-phase synthesis and work with air-sensitive materials.

Prerequisites: CHEM 351f

REQUIRED TEXTS:

Silverstein, R. M.; Webster, F.X.; Kiemle, D. J.; Bryce, D.L. Spectrometric Identification of Organic Compounds, 8th Edition, John Wiley & Sons, Inc.; New York, 2014.
Zubrick, J. W. The Organic Chem Lab Survival Manual 9th Edition; John Wiley & Sons, Hoboken, NJ, 2004.

MARK DISTRIBUTION IN PERCENT:

Midterm Exam (open book)	15%
Final Exam (open book)	20%
Assignments	15%
Laboratory	45%
Participation	5%
	100%

COURSE OBJECTIVES:

To develop competence and confidence in the use of organic laboratory techniques of synthesis, separation and characterization.
To gain expertise in the hands-on use of modern spectroscopic tools for determination of molecular structure, including NMR, IR, GC-MS and UV-VIS
To actively search and read scientific literature and to practice writing formal scientific reports
To encourage positive, constructive interaction and collaboration amongst students and between students and instructors
To recognize your roles and responsibilities in the collection, interpretation and dissemination of scientific data

SCHEDULE OF TOPICS:

Physical properties of organic compounds and purity
Separation & Purification Techniques

Chromatography

Extraction

Distillation

Crystalllization

Spectroscopic techniques

Mass Spectrometry (MS)

Infrared Spectroscopy (IR)

NMR (including heteronuclear and multidimensional NMR)

UV-VIS

Laboratory Research

Designing experiments and working in the lab

Report Writing

Required texts, assignments, and grade distributions may vary from one offering of this course to the next. Please consult the course instructor for up to date details.