| TERM: | 2021-22 Winter |
| COURSE NUMBER: |
CHEM 351 |
| COURSE TITLE: |
Organic Chemistry II |
| NAME OF INSTRUCTOR: |
Course Instructor: Dr. Peter Mahaffy
Laboratory Instructors: Dr. Heather Starke
|
| CREDIT WEIGHT AND WEEKLY TIME DISTRIBUTION: |
credits 3(hrs lect 3 - hrs sem 0 - hrs lab 3) |
| COURSE DESCRIPTION: |
A continuation of CHEM 350.
Prerequisites: CHEM 350 |
| COURE MATERIALS: |
- John E. McMurry, Bundle Organic Chemistry, 9th Edition print
version plus required OWL v2 subscription for electronic access to
problems, etc. as well as the digital e-book for McMurry ISBN:
9781305813366, (Mandatory, Essential toPass the Course.)
- Slupsky, C.; Mahaffy, P.G.; and Starke, H. The King's University: Chemistry 350/351 Laboratory
Experiments, 2021-2022 Edition, The King’s University; Edmonton. (REQUIRED)
- Safety glasses, one hardcover notebook (see lab manual) and a set of molecular models. (REQUIRED)
- Computer
or tablet with a camera (or a webcam) for accessing any on-line
lectures that are scheduled. (required) Smartphones are not recommended.
- Access to Moodle: http://moodle.kingsu.ca
- James
W Zubrick, The Organic Chem Lab Survival Manual: A Student's Guide to
Techniques, A recent edition, Optional, Helpful to Complete Assignments
(The 10th edition is also available electronically through the campus
ebookstore link above)
- Wavefunction, Inc. Spartan Molecular Modeling and Odyssey Molecular Dynamics Software (Site
license available in all campus computer labs)
|
| MARK DISTRIBUTION IN PERCENT: |
|
| Laboratory |
25% |
| Midterm | 20% |
| Final Exam |
25% |
| Problems, Quizzes, Participation | 30% |
|
|
|
100% |
|
| COURSE OBJECTIVES: |
- To
develop understanding and appreciation
for the importance of organic
chemistry and the ubiquitous nature of carbon compounds in everyday life.
- To understand the fundamental relationship between molecular structure and chemical reactivity.
- To
find patterns in the many reactions of carbon compounds by thoroughly
understanding a set of reaction mechanisms and
the patterns of reactivity of
functional groups, and employing basic
synthetic strategies. This semester, we will explore the chemistry of
aromatic compounds, alcohols (and thiols), amines, and carbonyl
containing compounds. We will end by looking at the chemistry of
important biomolecules, such as carbohydrates and proteins.
- To develop basic
competence and confidence in the
use of organic laboratory techniques of
synthesis, separation and characterization.
- To
gain expertise in the hands-on use
of modern spectroscopic tools for
determination of molecular structure, including NMR, IR, and
GC-MS.
- To be aware of the historical contexts, developments,
and philosophical presuppositions that have given rise to modern
organic chemistry.
- To be aware of
the professional responsibility of
chemists for the materials they
make, and to make conscious ethical choices about their
potential uses and abuses.
- To encourage positive, constructive interaction and collaboration amongst students and between students and instructors.
|
| LECTURE OUTLINE: |
- Review of key mechanisms, reactions, & concepts from Chem 350
- Structure Determination –1H NMR Spectroscopy
- Structure Determination – Mass Spectrometry
- Integrated methods for spectroscopic structure determination
- Alcohols & Phenols
- Ethers & Epoxides, Thiols & Sulfides-Garlic Chem
- Aromaticity & heterocycles
- Electrophilic aromatic substitution
- Carbonyl Compounds, Aldehydes & Ketones, Nucleophilic addition
- Aldehydes & Ketones, Nucleophilic addition
- Carboxylic Acids and Derivatives
- Nucleophilic Acyl Substitution
- Carbonyl -Substitution Reactions & condensation
- Amines & heterocycles
- Biomolecules: Carbohydrates
- Biomolecules: Amino Acids, Peptides, Proteins
- Pulling it together: Bio-organic chemistry of Covid-19
|
| LAB OUTLINE: | - January 10, 11 No labs
- January 17, 18 Qualitative Organic Analysis of an Unknown – independent activity; no scheduled lab period
- January 24, 25 Check in; Oxidation of Cyclohexanol with Household Bleach-week 1
- January 31
- February 1 Oxidation of Cyclohexanol with Household Bleach-week 2
- February 7, 8 No labs
- February 14, 15 Chemical Literature Project
- February 21, 22 Reading Week – no labs
- February 28
- March 1 Grignard Synthesis of Triphenylmethanol – Week 1
- March 7, 8 Grignard Synthesis of Triphenylmethanol – Week 2
- March 14, 15 Grignard Synthesis of Triphenylmethanol – Week 3
- March 21, 22 No labs. Grignard paper and Lab book scan due Friday March 25.
- March 28, 29 Synthesis of Aspirin
- April 4. 5 Proteins and Carbohydrates; check out
|
THE KING'S UNIVERSITY