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TERM:2021-22 Fall
COURSE NUMBER: CHEM 350
COURSE TITLE: Organic Chemistry I
NAME OF INSTRUCTOR: Dr Peter Mahaffy
CREDIT WEIGHT AND WEEKLY TIME DISTRIBUTION: credits 3 (hrs lect 3 - hrs sem 0 - hrs lab 3)
COURSE DESCRIPTION: The chemistry of carbon compounds. Structure-reactivity relationships, mechanism, stereochemistry, and spectroscopy are emphasized in the study of the main classes of organic compounds. Particular attention is paid to compounds of importance to biology and the chemical industry.

Prerequisites: CHEM 201
COURSE MATERIALS:
  • John E. McMurry, Bundle Organic Chemistry, 9 th Edition print version plus required  OWL v2 subscription for electronic access to problems, etc. as well as the digital ebook for McMurry ISBN: 9781305813366, (Mandatory, Essential to Pass the Course.)
  • James W Zubrick, The Organic Chem Lab Survival Manual: A Student's Guide to Techniques, A recent edition, Optional, Helpful to Complete Assignments (The 10th edition is also available electronicallythrough the campusebookstore link above)
  • Wavefunction, Inc. Spartan Molecular Modelling and Odyssey (available in computer labs)
  • Also required are safety glasses, one hardcover notebooks (see lab manual) and a set of molecular models. Laboratory coat recommended.
  • Access to Moodle: http://moodle.kingsu.ca
MARK DISTRIBUTION IN PERCENT:
Laboratory 25%
Exam 1 15%
Exam 2 17%
Final Exam 25%
Problems, quizzes, participation 18%
100%
COURSE OBJECTIVES AND GUIDELINES: Learning outcomes are statements that describe the key content, skills, or values that you will be able to
demonstrate, or describe, upon successfully completing this course. The learning outcomes for Chem 350 are
grouped into six main categories, as listed below.
  • A. Depth and Breadth of Knowledge
    • Demonstrate an understanding of the many reactions of carbon compounds by thoroughly understanding a set of reaction mechanisms and the patterns of reactivity of functional groups and employing basic synthetic strategies.
    • Develop an understanding and appreciation for the importance of organic chemistry and the ubiquitous nature of carbon compounds in everyday life.
    • Understand the fundamental relationship between molecular structure and chemical reactivity.
    • Describe the historical contexts, developments, and philosophical presuppositions that have given rise to modern organic chemistry
  • B. Knowledge of Methodologies
    • Describe, perform and/or interpret experiments that could be used to carry out a particular transformation
    • Describe how modern spectroscopic tools can be used to elucidate the structure of organic compounds
  • C. Application of Knowledge
    • Apply your understanding of structure and reactivity to explain or predict a given transformation
    • Through hands-on activities, develop competence and confidence that display mastery of techniques (related to synthesis, separation, and characterization), and the safe use and disposal of chemicals
    • Gain expertise in the hands-on use of modern spectroscopic tools for determination of molecular structure, including NMR, IR, and GC-MS
  • D. Communication Skills
    • Use terminology and conventions appropriate to organic chemistry (including IUPAC rules for the nomenclature of molecules and reaction mechanisms) to communicate your understanding
    • Maintain detailed and accurate lab notebooks
    • Appropriately communicate disciplinary knowledge to a variety of audiences (specialists and nonspecialists) and in various settings (egg: group work, oral exams, laboratory reports) 
  • E. Awareness of the Limits of Knowledge
    • Use various types of models of molecular bonding/structure and understand their strengths and limitations
    • Recognize organic chemistry as one approach to explaining the physical world
  • F. Maturity and Professional Capacity
    • Conduct yourself with professionalism (honesty, integrity, and concern for others) in both the lab and classroom setting
    • Explain the professional responsibility of chemists for the materials they make, and to make conscious ethical choices about the potential uses and abuses of these substances.
    • Work with your peers to foster positive and constructive interaction
COURSE OUTLINE:
  • #1 Introduction, review from Intro Chem: Lewis structures, Bonding, VSEPR, Hybridization, Resonance, Polar Covalent Bonds
  • #2: Acids & Bases, with emphasis on Lewis Acids and Bases
  • #3: Organic compounds: alkanes
  • #3: Structure elucidation – IR and 13C NMR
  • #4: Cycloalkanes and conformational analysis
  • #5: Overview of Organic reactions
  • #6: Alkenes – Properties, Preparation and Reactions
  • #7: Alkynes, Introduction to Synthesis
  • #8: Stereochemistry & Chirality
  • #9: Organohalides
  • #10: Nucleophilic Substitution & Elimination
  • #11: Structure Determination –1H NMR Spectroscopy
LAB OUTLINE:
  • September 13, 14 Introduction to the Laboratory: Orientation, check-in, and safety review
  • September 20, 21 Extraction of Caffeine from Cola Syrup
  • September 27, 28 Infrared and NMR Spectroscopy for Structural Interpretation
  • October 4, 5 Thin Layer Chromatography of Drug Components
  • October 11, 12 No Labs - Thanksgiving
  • October 18, 19 Simple and Fractional Distillation of Petroleum Hydrocarbons
  • October 25, 26 Introduction to the Chemical Literature
  • November 1, 2 Isolation of an Essential Oil from Cloves – Week 1
  • November 8. 9 Isolation and Characterization of Clove Oil Components – Week 2
  • November 15, 16 Characterization of Clove Oil components – Week 3
  • Preparing a publishable style paper
  • November 22, 23 Spartan Modelling of Essential Oil Components (independent exercise)
  • November 29, 30 The Mutarotation Constant of Glucose
  • Check out and clean up
  • December 6, 7 No labs, Last week of classes


Required texts, assignments, and grade distributions may vary from one offering of this course to the next. Please consult the course instructor for up to date details.

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