| TERM: | 2020-21 Fall |
| COURSE NUMBER: |
BIOL 422 |
| COURSE TITLE: |
Molecular Genetics |
| NAME OF
INSTRUCTOR: |
Dr. Annerieke Wolmarans |
| CREDIT WEIGHT
AND WEEKLY TIME DISTRIBUTION: |
credits 3 (hrs lect 3 - hrs sem 0 - hrs lab 3) |
| CALENDAR
DESCRIPTION: |
A detailed examination of the genetic and biochemical
control of cell structure and function. Topics included
are:biomolecular structure and function, DNA replication and
recombination, regulation of transcription and translation, genomics,
and gene control in development. Special emphasis is placed on the
tools of molecular genetic analysis. The laboratory work is designed to
provide hands-on experience with current molecular genetics techniques.
Prerequisites: BIOL 320
Corequisites: BIOL 470 or CHEM 400 |
| REQUIRED
MATERIALS: |
- Molecular Cell Biology (eighth edition). Lodish et al. 2016. W.H. Freeman, New York. ISBN-13: 978-14641-8339-3.
- Hardcover, lined lab notebook (available from bookstore)
- Lab coat (available from bookstore)
- Laboratory manual (only available on Moodle):
- Biology 422 Laboratory Manual, Fall 2020, The King’s University
|
| MARK
DISTRIBUTION IN PERCENT: |
| Attendance/Discussions | 4% |
| Assignments |
6% |
| Quizzes |
12% |
| Midterm I |
15% |
| Midterm II |
15% |
| Final Exam |
18% |
| Lab | 30% |
|
100 % |
|
| COURSE
OBJECTIVES: |
Upon successful completion of this course, students
will be able to:
Give an overview of a cell, its structures and chemical makeup
- Describe the structure and function of proteins
- Describe common techniques and tools to culture, visualize and study cells
- Describe and apply common molecular biology techniques for the study of DNA and proteins
- Understand the multiple levels of the control of gene expression, and discuss their impact on normal cellular function
|
| LECTURE TOPICS: |
- Overview of molecular cell biology
- Chemical Foundations
- Protein structure and function
- Studying Proteins
- Culturing and Visualizing Cells
- Nucleic acids, RNA and transcription
- Translation and DNA replication
- DNA Repair and Recombination
- Studying Genes using Mutations
- DNA Cloning and Characterization
- Expression Analysis
- Eukaryotic Gene Structure
- Transposable (mobile) DNA elements
- Genes, genomics, and chromosomes
- Transcriptional control of gene expression
- Control of Gene Expression in Eukaryotes
- Epigenetics
- Processing of Eukaryotic pre-mRNA
- mRNA Processing and Transport
- Post-transcriptional gene control
|
THE KING'S UNIVERSITY